Hepatic Failure following Metronidazole in Children with Cockayne Syndrome
نویسندگان
چکیده
منابع مشابه
Metronidazole Toxicity in Cockayne Syndrome: A Case Series.
Cockayne syndrome (CS) is a rare genetic disorder characterized by small stature, intellectual disability, and accelerated pathologic aging. Through the Cockayne Syndrome Natural History Study, we have identified 8 cases of acute hepatic failure after metronidazole administration (8% of our cohort), 3 of which were fatal. The interval between initial administration and death was 6 to 11 days. T...
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Many diseases may present as acute hepatic failure in the pediatric age group, including viral hepatitis A and B, adverse drug reactions, both toxic and "hepatitic," and inherited metabolic disorders such as tyrosinemia, alpha 1 antitrypsin deficiency, and Wilson's disease. Management is primarily supportive, with care taken to anticipate the known complications of hepatic failure. Few "curativ...
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ژورنال
عنوان ژورنال: Case Reports in Pediatrics
سال: 2020
ISSN: 2090-6803,2090-6811
DOI: 10.1155/2020/9634196